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[Lung transplantation in cystic fibrosis: perioperative mortality].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Padilla, Jose I. Calvo, Víctor Daniel Jordá, Carlos Escrivá, Juan Cerón, José María Castro Peñalver, Juan Carlos García-Zarza, Angel Pastor, J. F. Soriano Blasco, Eduardo |
| Copyright Year | 2005 |
| Abstract | OBJECTIVE To determine the incidence and causes of perioperative mortality following lung transplant for cystic fibrosis. PATIENTS AND METHODS We analyzed the cases of 57 patients. Fifty-five patients received double lung transplants, 1 received a heart-double lung transplant, and 1 received a combined double lung and liver transplant. Information related to the organ donor, recipient, lung graft, and early postoperative period was gathered. Perioperative mortality was defined as death resulting from anesthesia or surgery regardless of how many days had passed. The Kaplan-Meier method was used to analyze survival. A Cox logistic regression model was used to determine variables affecting mortality. RESULTS Survival was 83.7% at 1 year after transplantation, 77.3% at 2 years, and 66.9% at 5 years. Five (8.7%) patients died as a result of anesthesia or surgery. A ratio of PaO2 to inspired oxygen fraction (FiO2) less than 200 mm Hg in the early postoperative period was observed in 8 (14%) patients. Primary graft failure occurred in 4 patients, due to pneumonia in 2 and to biventricular dysfunction in 2. Three of those patients died. Two patients with PaO2/FiO2 greater than 200 mm Hg died after surgery, one from septic shock due to Pseudomonas cepacia and the other from massive cerebral infarction. PaO2/FiO2 upon admission to the recovery care unit was the only variable significantly associated with perioperative mortality in the logistic regression model (P=.0034). CONCLUSIONS The only factor significantly related to perioperative mortality in patients receiving transplants for cystic fibrosis was PaO2/FiO2 upon admission to the recovery unit. |
| Starting Page | 529 |
| Ending Page | 531 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.archbronconeumol.org/index.php?p=revista&pii=13078650&tipo=pdf-simple |
| Alternate Webpage(s) | http://apps.elsevier.es/watermark/ctl_servlet?_f=10&accion=L&fichero=260v41n09a13079309pdf001.pdf&lan=en&origen=bronco&pcontactid=&pident_articulo=13079309&pident_revista=260&pident_usuario=0&ty=32&web=www.archbronconeumol.org |
| PubMed reference number | 16194511v1 |
| Volume Number | 41 |
| Issue Number | 9 |
| Journal | Archivos de bronconeumologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cerebral Infarction Cessation of life Cystic Fibrosis Inspiration function Liver Failure, Acute Liver diseases Lung Transplantation Lung diseases Mercury Oxygen measurement, partial pressure, arterial Partial Pressure Arterial Oxygen to Fraction Inspired Oxygen Ratio Measurement Patients Pneumonia Septic Shock Structure of parenchyma of lung Transplanted tissue Ventricular Dysfunction |
| Content Type | Text |
| Resource Type | Article |
