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PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jabbari, Esmaiel Florschutz, Anthony Vatroslav Lu, Lichun Liu, Nathan Pedersen, Larry G. Kempen, Diederik H. R. Currier, Bradford L. Yaszemski, Michael J. |
| Copyright Year | 2004 |
| Abstract | Introduction Human recombinant bone morphogenetic protein-2 (rhBMP-2) has been proven effective in stimulating the regeneration of bone in both skeletal and extraskeletal locations. Through encapsulation within, and release from, biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) microspheres the local concentration of rhBMP-2 could be maintained at optimal levels to stimulate bone regeneration [1]. The objective of this work was to investigate the effect of microsphere loading in a porous poly(propylene fumarate) (PPF) scaffold on release characteristics of rhBMP-2. |
| Starting Page | 1133 |
| Ending Page | 1136 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://folk.ntnu.no/skoge/prost/proceedings/aiche-2004/pdffiles/papers/068d.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |