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Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hammond, Bruce Katzenellenbogen, Benita S. Krauthammer, N. McConnell, John |
| Copyright Year | 1979 |
| Abstract | The chlorinated insecticide chlordecone (Kepone) interacts with the estrogen receptor system in the rat uterus in vitro and in vivo. It competes with estradiol for binding to the cytoplasmic receptor in vitro and also induces nuclear accumulation of estrogen receptor sites in uteri in vitro. When injected into immature rats, chlordecone translocates estrogen receptor sites to the uterine nucleus, increases uterine weight, and stimulates the synthesis of the progesterone receptor, an estrogen receptor-mediated process. Its slow onset of action but prolonged duration of interaction with estrogen receptor and stimulation of uterine weight gain and progesterone receptor synthesis indicates that, although it has an affinity for receptor only 0.01-0.04% that of estradiol, its considerable estrogenic activity may likely be derived from its long half-life and bioaccumulative character. |
| Starting Page | 49 |
| Ending Page | 59 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/76/12/6641.full.pdf |
| PubMed reference number | 93289v1 |
| Volume Number | 76 |
| Issue Number | 12 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Affinity Binding Sites Cell Nucleus Chlordecone Estradiol Estrogen Receptors Estrogens Heparin, Low-Molecular-Weight Kepone Progesterone Receptors, Cytoplasmic Uterus estrogen receptor alpha, human receptor biosynthetic process |
| Content Type | Text |
| Resource Type | Article |
