NDLI: Estrogen receptors in ovary and uterus of immature hamster and rat: effects of estrogens.

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Estrogen receptors in ovary and uterus of immature hamster and rat: effects of estrogens.

Content Provider	Semantic Scholar
Author	Kim, Inkyo Greenwald, Glenna
Copyright Year	1987
Abstract	Cytosolic and nuclear estrogen receptors in the ovary and uterus of immature rats and hamsters were determined to evaluate why exogenous estrogens were ineffective in stimulating follicular maturation in the hamster compared to the rat. Animals were injected sc with oil or single injection of 1 mg estradiol cyclopentylpropionate (ECP) on Day 23 or a daily injection of 2 mg diethylstilbestrol (DES) on Days 23-25 and killed on Day 26. Total binding sites for estrogen in ovarian cytosol of control hamsters were half the number in the rat ovary (28 fmole/mg protein) and about 50% of the receptors were occupied in the hamster. The apparent affinity of the estrogen-cytosol receptor complex was also lower in the hamster (Kd; 1.41 nM) than in the rat (Kd; 0.52 nM). After ECP treatment, there was a tendency for translocation in all 4 tissues examined even though some differences were not statistically significant. However, after DES treatment both cytosol and nuclear estrogen receptors decreased in both species. This discrepancy may be due to the difference in the time course of the nuclear translocation, the difference in metabolism and difference in the binding potencies of ECP and DES. The lack of ovarian responsiveness to estrogen in the hamster thus appears to be due to the reduced number of cytosol receptor sites which have a low affinity for estrogen and are already partially occupied.
Starting Page	45
Ending Page	53
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/endocrj1954/34/1/34_1_45/_pdf
PubMed reference number	3608913v1
Volume Number	34
Issue Number	1
Journal	Endocrinologia japonica
Language	English
Access Restriction	Open
Subject Keyword	Affinity Binding Sites Biologic Development Body tissue Cytoplasmic matrix Diethylstilbestrol Estradiol Estrogen Receptors Estrogens Hamsters Ovary Stimulation (motivation) ovarian neoplasm
Content Type	Text
Resource Type	Article

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