NDLI: Red-emissive azabenzanthrone derivatives for photodynamic therapy irradiated with ultralow light power density and two-photon imaging† †Electronic supplementary information (ESI) available: Experimental details for the synthesis, 1H/13C NMR spectra, IR spectra, HRMS spectra, and absorption and emiss

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Red-emissive azabenzanthrone derivatives for photodynamic therapy irradiated with ultralow light power density and two-photon imaging† †Electronic supplementary information (ESI) available: Experimental details for the synthesis, 1H/13C NMR spectra, IR spectra, HRMS spectra, and absorption and emiss

Content Provider	Semantic Scholar
Author	Zang, Qiguang Yu, Jiayi Yu, Wenbin Qian, Jun Hu, Rongrong Tang, Ben Zhong
Copyright Year	2018
Abstract	Photodynamic therapy has proved to be an effective strategy for cancer therapy, and advanced photosensitizers for image-guided photodynamic therapy require biocompatibility, intense absorption, high ROS generation efficiency, phototoxicity, low irradiation power density and efficient emission. In this work, four red emissive azabenzanthrone derivatives have been designed and synthesized, which generally exhibit efficient aggregated state emission. Through structural optimization, 3-diphenylamino-11-azabenzanthrone was found to show satisfactory photo-induced ROS generation and high emission efficiency in the aggregated state. Under the irradiation of a white LED lamp with an ultralow power density of 1.67 mW cm-2, this compound demonstrates significant photo-induced cytotoxicity toward HeLa cells. Moreover, deep tissue penetration can be realized by two-photon imaging of mouse brain vessels with these azabenzanthrone derivatives at vertical depths of up to 280 μm, attributed to the large emission wavelength and efficient emission.
Starting Page	5165
Ending Page	5171
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1039/c8sc00633d
PubMed reference number	29997869
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/sc/c8sc00633d/c8sc00633d1.pdf
Alternate Webpage(s)	http://pubs.rsc.org/en/content/articlepdf/2018/sc/c8sc00633d
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2018/sc/c8sc00633d
Alternate Webpage(s)	https://doi.org/10.1039/c8sc00633d
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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