NDLI: Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.

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Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.

Content Provider	Semantic Scholar
Author	Heckbert, Susan R. Hindorff, Lucia A. Edwards, Karen L. Psaty, Bruce M. Lumley, Thomas S. Siscovick, David S. Tang, Zhong-Hua Durda, J. Peter Kronmal, Richard A. Tracy, Russell P.
Copyright Year	2003
Abstract	BACKGROUND Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events. CONCLUSIONS The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.
Starting Page	e518
Ending Page	e524
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/107/15/2021.full.pdf
PubMed reference number	12682000v1
Volume Number	107
Issue Number	15
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic Receptor Cardiovascular Diseases Cerebral Infarction Cerebrovascular accident Codon (nucleotide sequence) Genetic Polymorphism Hazard Ratio Hereditary Diseases Homozygote Hypertensive disease Myocardial Ischemia
Content Type	Text
Resource Type	Article

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