Loading...
Please wait, while we are loading the content...
Similar Documents
Association of electrocardiographic left ventricular hypertrophy with incident cardiovascular disease in Japanese older hypertensive patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Edison, Eijiro Sugiyama Yano, Yuichiro Hoshide, Satoshi Kario, Kazuomi |
| Copyright Year | 2015 |
| Abstract | BACKGROUND Our aim was to assess whether electrocardiographic left ventricular hypertrophy (ECG-LVH) is associated with a higher risk of cardiovascular disease (CVD) events, independent of 24-hour blood pressure (BP) and circulating levels of norepinephrine and hemostatic factors. METHODS In 514 older hypertensive patients (mean age 72.3 years; 37% men), we assessed ambulatory BP values, circulating levels of norepinephrine and hemostatic factors (plasma fibrinogen, prothrombin fragment 1+2 (F1+2), von Willebrand factor (vWF), and plasminogen activator inhibitor-1 (PAI-1)), and the presence or absence of ECG-LVH (Sokolow-Lyon voltage ≥ 3.5 mV). The incidence of CVD events (i.e., myocardial infarction and stroke) was prospectively ascertained. RESULTS During an average 41 months of follow-up (1,751 person-years), 43 stroke and 3 myocardial infarction events occurred. At baseline, patients with ECG-LVH had higher mean 24-hour BP (148.8/83.8mm Hg vs. 135.7/77.2mm Hg) and circulating norepinephrine levels (404.6 pg/ml vs. 336.3 pg/ml) compared to those without ECG-LVH; the differences remained unchanged after adjustment for age, gender, smoking status, presence of diabetes, and antihypertensive medication uses at follow-up time (all P < 0.01). Cox proportional hazards models suggested that the hazard ratio (HR; 95% confidence interval (CI)) of CVD events for those with ECG-LVH was 4.4 (2.3-8.2), and the association between ECG-LVH and incident CVD events remained significant after adjustment for high 24-hour BP (≥130/80mm Hg), nocturnal SBP, circulating norepinephrine and fibrinogen levels (HRs, 3.5-4.2, all P < 0.001). CONCLUSIONS In older hypertensive patients, ECG-LVH was associated with a higher risk of CVD events, independent of ambulatory BP parameters and circulating norepinephrine and fibrinogen levels. |
| Starting Page | 428 |
| Ending Page | 429 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jichi-ir.jichi.ac.jp/index.php?action=pages_view_main&active_action=repository_action_common_download&attribute_id=20&block_id=32&file_no=1&item_id=333&item_no=1&page_id=13 |
| PubMed reference number | 25267736v1 |
| Alternate Webpage(s) | https://doi.org/10.1093/ajh/hpu184 |
| DOI | 10.1093/ajh/hpu184 |
| Journal | American journal of hypertension |
| Volume Number | 28 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antihypertensive Agents Cardiovascular Diseases Cerebrovascular accident Confidence Intervals Diabetes Mellitus Electrocardiography Hazard Ratio Hemostatic Agents Hypertensive disease Left Ventricular Hypertrophy Myocardial Infarction Norepinephrine Patients Status Epilepticus Ventricular Dysfunction, Left alteplase prothrombin fragment 1.2 |
| Content Type | Text |
| Resource Type | Article |
