NDLI: Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding.

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Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding.

Content Provider	Semantic Scholar
Author	Claeys, Bart Vervaeck, Anouk Hillewaere, Xander K. D. Possemiers, Sam Hansen, Laurent Beer, Thomas De Remon, Jean Paul Vervaet, Chris
Copyright Year	2015
Abstract	This study evaluated thermoplastic polyurethanes (TPUR) as matrix excipients for the production of oral solid dosage forms via hot melt extrusion (HME) in combination with injection molding (IM). We demonstrated that TPURs enable the production of solid dispersions - crystalline API in a crystalline carrier - at an extrusion temperature below the drug melting temperature (Tm) with a drug content up to 65% (wt.%). The release of metoprolol tartrate was controlled over 24h, whereas a complete release of diprophylline was only possible in combination with a drug release modifier: polyethylene glycol 4000 (PEG 4000) or Tween 80. No burst release nor a change in tablet size and geometry was detected for any of the formulations after dissolution testing. The total matrix porosity increased gradually upon drug release. Oral administration of TPUR did not affect the GI ecosystem (pH, bacterial count, short chain fatty acids), monitored via the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). The high drug load (65 wt.%) in combination with (in vitro and in vivo) controlled release capacity of the formulations, is noteworthy in the field of formulations produced via HME/IM.
Starting Page	44
Ending Page	52
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1016/j.ejpb.2014.11.003
PubMed reference number	25448075
Journal	Medline
Volume Number	90
Alternate Webpage(s)	https://biblio.ugent.be/publication/5936157/file/6860696.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.ejpb.2014.11.003
Journal	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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