Loading...
Please wait, while we are loading the content...
Similar Documents
A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices
| Content Provider | Scilit |
|---|---|
| Author | Verstraete, G. Mertens, P. Grymonpré, W. Bockstal, P. J. Van Beer, T. De Boone, M. N. Hoorebeke, L. Van Remon, J. P. Vervaet, C. |
| Copyright Year | 2016 |
| Description | Journal: International Journal of Pharmaceutics During this project 3 techniques (twin screw melt granulation/compression (TSMG), hot melt extrusion (HME) and injection molding (IM)) were evaluated for the manufacturing of thermoplastic polyurethane (TPU)-based oral sustained release matrices, containing a high dose of the highly soluble metformin hydrochloride. Whereas formulations with a drug load between 0-70% (w/w) could be processed via HME/(IM), the drug content of granules prepared via melt granulation could only be varied between 85-90% (w/w) as these formulations contained the proper concentration of binder (i.e. TPU) to obtain a good size distribution of the granules. While release from HME matrices and IM tablets could be sustained over 24h, release from the TPU-based TSMG tablets was too fast (complete release within about 6h) linked to their higher drug load and porosity. By mixing hydrophilic and hydrophobic TPUs the in vitro release kinetics of both formulations could be adjusted: a higher content of hydrophobic TPU was correlated with a slower release rate. Although mini-matrices showed faster release kinetics than IM tablets, this observation was successfully countered by changing the hydrophobic/hydrophilic TPU ratio. In vivo experiments via oral administration to dogs confirmed the versatile potential of the TPU platform as intermediate-strong and low-intermediate sustained characteristics were obtained for the IM tablets and HME mini-matrices, respectively. |
| Related Links | https://biblio.ugent.be/publication/8510740/file/8516729.pdf |
| Ending Page | 611 |
| Page Count | 10 |
| Starting Page | 602 |
| ISSN | 03785173 |
| e-ISSN | 18733476 |
| DOI | 10.1016/j.ijpharm.2016.09.072 |
| Journal | International Journal of Pharmaceutics |
| Issue Number | 1-2 |
| Volume Number | 513 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Pharmaceutics Pharmacology and Pharmacy Hot Melt Extrusion Twin Screw Melt Granulation High Drug Load Sustained Release Thermoplastic Polyurethanes Metformin Hydrochloride |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
