NDLI: La mesure du monoxyde d'azote (NO) dans l'air expiré comme marqueur inflammatoire des voies aériennes Measurement of exhaled nitric oxide (NO) as a marker of airway inflammation

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La mesure du monoxyde d'azote (NO) dans l'air expiré comme marqueur inflammatoire des voies aériennes Measurement of exhaled nitric oxide (NO) as a marker of airway inflammation

Content Provider	Semantic Scholar
Author	Duong-Quy, Sy Hua-Huy, Thông
Copyright Year	2013
Abstract	SUMMARY Detection of NO from bronchopulmonary origin in exhaled air is now possible through measuring devices using the prin- ciple of chemiluminescence. The major technical advantage of these devices is to allow to measure the fraction of NO in gaseous form, of the order of 1 part per billion (ppb). In healthy subject, the concentration of NO measured in exhaled air varied from 5 to 25 ppb during a quiet ventilation in normoxia. It is likely that a small part of the concentration of NO quantity measured in exhaled air comes from either alveoli or small airways. The consisting findings showing that there is an increase of NO quantity formed in the lung of subjects with asthma, suggests on the one hand, the involvement of inducible NOS in bronchial inflammation of asthma and justifies on the other hand, the use of exhaled NO measurement as biomarker of bronchial inflammation. The most considerable advantage of the measurement of exhaled NO in comparison with other classical conventional ex- plorations is that this method can directly assess the phenomenon of airway inflammation that characterizes the pathology of asthma while other techniques measure only secondary changes of ventilation. The sensitivity of the measurement of NO is considered better than that of FEV1, because of a significant change of FENO occurs very early for 2 weeks while a change in FEV is detectable after 3 months.
File Format	PDF HTM / HTML
DOI	10.12699/jfvp.4.11.2013.16
Alternate Webpage(s)	http://www.afvp.info/vietnamien/galleryUpload/1647_REVIEW3-N11.pdf
Alternate Webpage(s)	https://doi.org/10.12699/jfvp.4.11.2013.16
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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