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Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel
| Content Provider | Semantic Scholar |
|---|---|
| Author | Abdallah, Marwa H. Sabry, Shereen Ahmed Hasan, Azza A. |
| Copyright Year | 2016 |
| Abstract | Objective: The aim of this study is to formulate and evaluate proniosomal gel formulations as transdermal delivery systems of glimepiride (GM) to improve its therapeutic efficacy. Methods: Proniosomal formulations have been prepared using different types of non-ionic surfactants with cholesterol in different molar ratios. Proniosomal gel; PN 16 (Span 60, Tween 60, Cholesterol; 35:35:30 molar ratio) that exhibits maximum EE % (94.01 ± 0.88) and most prolonged release was chosen for ex-vivo skin permeation and in-vivo hypoglycemic activity studies. Results: Proniosomal gel produced better permeation through rabbit skin than HPMC niosomal gel and HPMC gel. The pharmacokinetic parameters; time of maximum response (T max ), % reduction in blood glucose concentration and area above the blood glucose levels-time curve (AAC) of proniosomal gel were studied. Proniosomal gel showed a controlled release behavior and a significantly higher hypoglycemic activity (65.34 ± 6.54%). Conclusion: It is evident from this study that proniosomal gel can act as an alternative approach for enhancing transdermal delivery of GM. Key words: Glimepiride, Hypoglycemic activity, Nonionic surfactants, Proniosomal gel, Area above the blood glucose levels-time curve. |
| Starting Page | 335 |
| Ending Page | 340 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.5530/jyp.2016.4.8 |
| Volume Number | 8 |
| Alternate Webpage(s) | http://www.jyoungpharm.org/sites/default/files/10.5530jyp.2016.4.8.pdf |
| Alternate Webpage(s) | https://doi.org/10.5530/jyp.2016.4.8 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
