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Some lung cellular parameters reflecting inflammation after combined inhalation of amosite dust with cigarette smoke by rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Beňo, Milan Hurbánková, Marta Dušinská, Mária Volkovová, Katarína Staruchová, Marta Černa, Silvia Barancokova, Magda Kazimírová, Alena Kováčiková, Zuzana C. Bobek, P. R. Horecký, Miloš Mikulecký, Miroslav Kyrtopoulos, Soterios A. |
| Copyright Year | 2004 |
| Abstract | Cellular changes were followed in lung cell suspensions after 175 day inhalation by rats of concentrations 30 mg/m3 or 60 mg/m3 of amosite asbestos every second day combined with daily exposure to cigarette smoke at 30 mg of total particulate matter (TPM)/m3 air. Concomitantly, lung inflammation was assessed by changes in the bronchoalveolar lavage fluid (BALF). A dose-dependent rise in the BALF inflammatory parameters was found. The rise of the proportion of binucleate (BNC) and multinucleate cells (MNC) in lung cell suspensions was also dose-dependent. It is concluded that, in the experimental assessment of effects of fibrogenic dusts, the number of BNC and of MNC in lung cell suspensions may serve as a useful semiquantitative biomarker of the inflammation. |
| Starting Page | 2530 |
| Ending Page | 2533 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://apps.szu.cz/svi/cejph/archiv/2004-sup-04-full.pdf |
| Alternate Webpage(s) | https://cejph.szu.cz/pdfs/cjp/2004/88/04.pdf |
| PubMed reference number | 15141963v1 |
| Volume Number | 12 |
| Journal | Central European journal of public health |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Asbestos Asbestos, Amosite Bronchoalveolar Lavage Fluid Inspiration function Irrigation M3 Mental Health Checklist Microgram per Liter Particulate (substance) Particulate Matter Pneumonia Structure of parenchyma of lung Suspensions |
| Content Type | Text |
| Resource Type | Article |
