NDLI: Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

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Varied dose exposures to ultrafine particles in the motorcycle smoke cause kidney cell damages in male mice

Content Provider	Semantic Scholar
Author	Wardoyo, Arinto Y. P. Juswono, Unggul Pundjung Noor, Johan A. E.
Copyright Year	2018
Abstract	Ultrafine particles (UFPs) are one of motorcycle exhaust emissions which can penetrate the lung alveoli and deposit in the kidney. This study was aimed to investigate mice kidney cell physical damage (deformation) due to motorcycle exhaust emission exposures. The motorcycle exhaust emissions were sucked from the muffler with the rate of 33 cm3/s and passed through an ultrafine particle filter system before introduced into the mice exposure chamber. The dose concentration of the exhaust emissions was varied by setting the injected time of the 20s, 40s, 60s, 80s, and 100s. The mice were exposed to the smoke in the chamber for 100 s twice a day. The impact of the ultrafine particles on the kidney was observed by identifying the histological image of the kidney cell deformation using a microscope. The exposure was conducted for 10 days. The kidney observations were carried out on day 11. The results showed that there was a significant linear correlation between the total concentration of ultrafine particles deposited in the kidneys and the physical damage percentages. The increased concentrations of ultrafine particles caused larger cell deformation to the kidneys.
Starting Page	383
Ending Page	389
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/j.toxrep.2018.02.014
PubMed reference number	29854608
Journal	Medline
Volume Number	5
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/12/main.PMC5977376.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.toxrep.2018.02.014
Journal	Toxicology reports
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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