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Triethyl ammonium sulphate catalyst one pot, Solvent free synthesis of novel Coumarin derivatives as antimicrobial agents.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nikalje, Anna Pratima G. Vazquez, Julio A. Seijas Vázquez-Tato, M. Pilar Tiwari, Shailee V. |
| Copyright Year | 2016 |
| Abstract | The work reports synthesis of 15 novel 3-((dicyclohexylamino)(substituted phenyl/heteryl)methyl)-4-hydroxy-2H-chromen-2-one derivatives 4 (a-o) as potential antimicrobial agents in solvent-free condition using Triethyl ammonium sulphate [Et3NH][HSO4] as an efficient, eco-friendly and reusable catalyst. Compared to other methods, this new method consistently has advantages, including excellent yields, a short reaction time, mild reaction conditions and catalyst reusability. The heterocyclic compound Coumarin, is associated with diverse biological activities of immense importance. Due to the presence of coumarin moiety in various pharmaceutically active compounds, we planned the green synthesis of a series of 15 novel compounds containing coumarin moiety coupled with dicyclohexyl rings by an eco-friendly ionic-liquid mediated protocol at room temperature by stirring. The structures of the synthesized compounds were confirmed by spectral characterization such as IR, 1H NMR, 13CNMR and Mass spectral studies. All the synthesized compounds 4 (a-o) were evaluated for anti-fungal and antibacterial activities and have exhibited promising antimicrobial activity. |
| Starting Page | 1 |
| Ending Page | 1 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.3390/ecsoc-20-f010 |
| Alternate Webpage(s) | https://sciforum.net/conference-paper/conference/ecsoc-20/paper/3647/download/pdf |
| Alternate Webpage(s) | https://doi.org/10.3390/ecsoc-20-f010 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
