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Catalyst-and solvent-free one-pot synthesis of some novel polyheterocycles from aryldiazenyl salicylaldehyde derivatives
| Content Provider | Semantic Scholar |
|---|---|
| Author | Parmar, Narsidas J. Patel, Rikin A. Teraiya, Shashikant B. Sharma, Deepak Gupta, Vivek Kumar |
| Copyright Year | 2012 |
| Abstract | A catalyst-and solvent-free domino/Knoevenagel-hetero-Diels–Alder (DKHDA) reaction of two aldyhyde substrates, allyl/prenyl ether tethered aryldiazenylsalicylaldehydes with corresponding pyrazolones and heterocyclic 1,3-diketones is described. Subsequent reduction of aryldiazenylpolyheterocycles, thus obtained in high yields (70–86%), afforded analogues amino frameworks with anticipated biological activity. While in a conventional procedure, no reaction was observed without activation of an allyl-based substrate, an excellent yield was achieved at higher temperature. For a prenyl based substrate, however it underwent smoothly to form a desired cyclised product. The stereochemistry of the compound was confirmed by various NMR experiments and a single crystal X-ray diffraction analysis. |
| Starting Page | 3069 |
| Ending Page | 3075 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C2RA00930G |
| Volume Number | 2 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ra/c2/c2ra00930g/c2ra00930g.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C2RA00930G |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |