NDLI: A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus

Content Provider	Semantic Scholar
Author	Fujiki, Minoru Kobayashi, Hidenori Inoue, Ryo Ishii, Keisuke
Copyright Year	2004
Abstract	The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against kainic acid (KA)-induced neurotoxicity. Pretreatment with a single oral GGA dose (800 mg/kg, 2 days before KA) significantly attenuated KA-induced seizures and cell death in rat hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-D-aspartate glutamate receptor antagonist, which indicates that the protection was indeed mediated by glutamate receptor activation.
Starting Page	281
Ending Page	285
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.brainres.2004.06.054
PubMed reference number	15342278
Journal	Medline
Volume Number	1021
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899304010522
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899304010522?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.brainres.2004.06.054
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus