Glycyrrhizin attenuates kainic Acid-induced neuronal cell death in the mouse hippocampus.

Content Provider	Europe PMC
Author	Luo, Lidan Jin, Yinchuan Kim, Il-Doo Lee, Ja-Kyeong
Copyright Year	2013
Abstract	Glycyrrhizin (GL), a triterpene that is present in the roots and rhizomes of licorice (Glycyrrhiza glabra), has been reported to have anti-inflammatory and anti-viral effects. Recently, we demonstrated that GL produced the neuroprotective effects with the suppression of microglia activation and proinflammatory cytokine induction in the postischemic brain with middle cerebral artery occlusion (MCAO) in rats and improved motor impairment and neurological deficits. In the present study, we investigated whether GL has a beneficial effect in kainic acid (KA)-induced neuronal death model. Intracerebroventricular (i.c.v.) injection of 0.94 nmole (0.2 µg) of KA produced typical neuronal death in both CA1 and CA3 regions of the hippocampus. In contrast, administration of GL (10 mg/kg, i.p.) 30 min before KA administration significantly suppressed the neuronal death, and this protective effect was more stronger at 50 mg/kg. Moreover, the GL-mediated neuroprotection was accompanied with the suppression of gliosis and induction of proinflammatory markers (COX-2, iNOS, and TNF-α). The anti-inflammatory and anti-excitotoxic effects of GL were verified in LPS-treated primary microglial cultures and in NMDA- or KA-treated primary cortical cultures. Together these results suggest that GL confers the neuroprotection through the mechanism of anti-inflammatory and anti-excitotoxic effects in KA-treated brain.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3699671&blobtype=pdf
ISSN	12262560
Journal	Experimental Neurobiology [Exp Neurobiol]
Volume Number	22
DOI	10.5607/en.2013.22.2.107
PubMed Central reference number	PMC3699671
Issue Number	2
PubMed reference number	23833559
e-ISSN	20938144
Language	English
Publisher	The Korean Society for Brain and Neural Science
Publisher Date	2013-06-27
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © Experimental Neurobiology 2013.
Subject Keyword	glycyrrhizinic acid KA neuroprotection anti-inflammation
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Cellular and Molecular Neuroscience