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Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ren, Yan-Bei Sun, Shang-Jun Han, Shuang-yin |
| Copyright Year | 2017 |
| Abstract | T-cell therapy using genetically engineered T cells modified with either T cell receptor or chimeric antigen receptor holds great promise for cancer immunotherapy. The concerns about its toxicities still remain despite recent successes in clinical trials. Temporal and spatial control of the engineered therapeutic T cells may improve the safety profile of these treatment regimens. To achieve these goals, numerous approaches have been tested and utilized including the incorporation of a suicide gene, the switch-mediated activation, the combinatorial antigen recognition, etc. This review will summarize the toxicities caused by engineered T cells and novel strategies to overcome them. |
| Starting Page | 78 |
| Ending Page | 83 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29283058v1 |
| Alternate Webpage(s) | https://doi.org/10.2174/1381612824666171227222624 |
| DOI | 10.2174/1381612824666171227222624 |
| Journal | Current pharmaceutical design |
| Volume Number | 24 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Cell Therapy Cellular Phone Chimera organism Chimeric antigen receptor Genetic Engineering Hematologic Neoplasms Hereditary Diseases Malignant Neoplasms Natural Science Disciplines Non-Small Cell Lung Carcinoma Organisms, Genetically Modified Patients Receptors, Antigen Synthetic Biology T-Lymphocyte T-cell receptor complex location cancer immunotherapy |
| Content Type | Text |
| Resource Type | Article |
