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Chimeric antigen receptor T-cell therapy to target hematologic malignancies.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kenderian, Saad Sirop Ruella, Marco Gill, Saar Kalos, Michael D. |
| Copyright Year | 2014 |
| Abstract | Several decades of humoral immunotherapy using monoclonal antibodies and cellular immunotherapy using hematopoietic cell transplantation have recently culminated in a successful merger: the development and clinical application of genetically engineered antibody-T cell chimeras. Also known as chimeric antigen receptor T cells (CAR T cells), these entities combine the exquisite antigen specificity of antibodies with the polyfunctionality and potency of cellular immunity and are a prime example of the potential for synthetic biology to treat disease. CAR T cells overcome several of the biologic obstacles that have historically hampered immunotherapy while providing fundamental mechanistic insights into cellular immunology and revealing new challenges in genetic engineering and target selection. Results from early-phase CAR T-cell-based clinical trials demonstrate the significant potential for this approach to affect dramatic and complete clinical responses while revealing novel toxicities associated with activation of potent and specific antitumor immunity. |
| Starting Page | 2882 |
| Ending Page | 2896 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cancerres.aacrjournals.org/content/canres/74/22/6383.full.pdf |
| PubMed reference number | 25371415v1 |
| Alternate Webpage(s) | https://doi.org/10.1158/0008-5472.CAN-14-1530 |
| DOI | 10.1158/0008-5472.can-14-1530 |
| Journal | Cancer research |
| Volume Number | 74 |
| Issue Number | 22 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Biological Factors Cell Therapy Cell Transplantation Cellular Immunity Cellular Immunology Cellular Phone Chimera organism Chimeric antigen receptor Genetic Engineering Hematologic Neoplasms Hematology (discipline) Hemopoietic stem cell transplant Hereditary Diseases Immunotherapy Leukemia, B-Cell Receptors, Antigen Synthetic Biology T-Lymphocyte |
| Content Type | Text |
| Resource Type | Article |
