Loading...
Please wait, while we are loading the content...
Similar Documents
Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Collingwood, Trevor N. Urnov, Fyodor D. Wolffe, Alan P. |
| Copyright Year | 1999 |
| Abstract | A contemporary view of hormone action at the transcriptional level requires knowledge of the transcription factors including the hormone receptor that may bind to promoters or enhancers, together with the chromosomal context within which these regulatory proteins function. Nuclear receptors provide the best examples of transcriptional control through the targeted recruitment of large protein complexes that modify chromosomal components and reversibly stabilize or destabilize chromatin. Ligand-dependent recruitment of transcriptional coactivators destabilizes chromatin by mechanisms including histone acetylation and contacts with the basal transcriptional machinery. In contrast, the recruitment of corepressors in the absence of ligand or in the presence of hormone antagonists serves to stabilize chromatin by the targeting of histone deacetylases. Both activation and repression require the action of other chromatin remodeling engines of the switch 2/sucrose non-fermentable 2 (SWI2/SNF2) class. Here we summarize this information and integrate hormone action into a chromatin context. |
| Starting Page | 2443 |
| Ending Page | 2446 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://jme.bioscientifica.com/downloadpdf/journals/jme/23/3/255.pdf |
| PubMed reference number | 10601972v1 |
| Volume Number | 23 |
| Issue Number | 3 |
| Journal | Journal of molecular endocrinology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Architecture as Topic Co-Repressor Proteins Glucocorticoid Receptor Gonadotropin-Releasing Hormone Receptor Histone Acetylation Histone Deacetylase Histones Hormone Antagonists Ligands Nucleoproteins Receptors, Nuclear Repression, Psychology TRANSCRIPTION FACTOR Thyroid Hormones Transcription, Genetic Transcriptional Regulation cellular targeting chromatin remodeling promoter |
| Content Type | Text |
| Resource Type | Article |
