NDLI: Fas ligand-induced caspase-1-dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease.

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Fas ligand-induced caspase-1-dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease.

Content Provider	Semantic Scholar
Author	Itoi, Hisayuki Fujimori, Yoshihiro Tsutsui, Hiroko Matsui, Kiyoshi Futatsugi, S. Okamura, Haruki Hara, Hiroshi H. Hada, Toshikazu Kakishita, Eizo Nakanishi, Kenji
Copyright Year	2001
Abstract	Acute graft-versus-host disease (aGVHD), the fatal side effects of bone marrow transplantation, was shown to be accompanied by elevation of serum levels of interleukin 18 (IL-18). In this study, the mechanism underlying the accumulation of IL-18 in aGVHD in mice was investigated. Lethally irradiated recipients having transplantation with H-2 disparate donor splenocytes demonstrated aGVHD and contained markedly elevated serum levels of IL-18. In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL-mediated IL-18 release in aGVHD. The wild-type hosts engrafted with caspase-1-deficient cells revealed marked increases of IL-18 similar to those engrafted with wild-type cells, whereas caspase-1-deficient recipients engrafted with wild-type cells showed only a slight elevation of serum IL-18, indicating that IL-18 elevation is derived from host cells in a caspase-1-dependent manner. These results suggest FasL-mediated caspase-1-dependent IL-18 secretion in aGVHD in mice.
Starting Page	46
Ending Page	49
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/98/1/235.full.pdf?sso-checked=true
PubMed reference number	11418486v1
Volume Number	98
Issue Number	1
Journal	Blood
Language	English
Access Restriction	Open
Subject Keyword	Acute GVH disease Bone Marrow Transplantation Contain (action) Fetal Alcohol Syndrome Graft-vs-Host Disease Interleukin-18 Interleukins Ligands Spleen Tissue Splenocyte Transplanted tissue
Content Type	Text
Resource Type	Article

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