NDLI: Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi

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Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi

Content Provider	Semantic Scholar
Author	Santander, Javier Roland, Kenneth L. Curtiss, Roy
Copyright Year	2008
Abstract	The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen display (VW variation) has been observed since the initial studies of S. Typhi. We have reported that the status of the rpoS gene is responsible for this phenomenon. We review the regulatory network of the Vi polysaccharide, linking osmolarity and RpoS expression. Also, we discuss how this may impact live attenuated Salmonella vaccine development.
Starting Page	412
Ending Page	420
Page Count	9
File Format	PDF HTM / HTML
DOI	10.3855/jidc.154
PubMed reference number	19745516
Journal	Medline
Volume Number	2
Alternate Webpage(s)	http://www.jidc.org/index.php/journal/article/viewFile/154/72
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/59/6d/nihms594928.PMC4100779.pdf
Alternate Webpage(s)	https://doi.org/10.3855/jidc.154
Journal	Journal of infection in developing countries
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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