NDLI: Pathological definition and evaluation of diabetic neuropathy and clinical correlations.

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Pathological definition and evaluation of diabetic neuropathy and clinical correlations.

Content Provider	Semantic Scholar
Author	Sima, Anders A. F.
Copyright Year	1994
Abstract	Diabetic neuropathy is a major complication of diabetes mellitus affecting to an equal extent type 1 and type 2 patients. Various mechanisms including metabolic and vascular abnormalities have been proposed to explain the progressive pathological changes that occur in peripheral nerve. Regardless of the precise mechanisms, structural abnormalities lead to functional changes which eventually result in the clinical manifestations of diabetic neuropathy. Possible interventions that may influence the progressive disease process include intensive insulin therapy and aldose reductase inhibitors. This article reviews the proposed pathogenetic mechanisms underlying diabetic neuropathy, their effects on nerve histomorphometric changes and ultrastructure typical of diabetic neuropathy, and potential therapeutic interventions and their impact on disease progression.
Starting Page	89
Ending Page	90
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D0D37EAC78262458DD29F5B0983FCE9E/S0317167100040695a.pdf/pathological_definition_and_evaluation_of_diabetic_neuropathy_and_clinical_correlations.pdf
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0317167100040695
PubMed reference number	7874608v1
Volume Number	21
Issue Number	4
Journal	The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Language	English
Access Restriction	Open
Subject Keyword	Aldehyde Reductase Cerebrovascular Disorders Congenital Abnormality Diabetes Mellitus Diabetic Neuropathies Metabolic Process, Cellular Patients Peripheral Nerves Progressive Disease aldose nervous system disorder
Content Type	Text
Resource Type	Article

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