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Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vinik, Aaron I. Erbaş, Tomris Casellini, Carolina M. |
| Copyright Year | 2013 |
| Abstract | One of the most overlooked of all serious complications of diabetes is cardiovascular autonomic neuropathy. There is now clear evidence that suggests activation of inflammatory cytokines in diabetic patients and that these correlate with abnormalities in sympathovagal balance. Dysfunction of the autonomic system predicts cardiovascular risk and sudden death in patients with type 2 diabetes. It also occurs in prediabetes, providing opportunities for early intervention. Simple tests that can be carried out at the bedside with real-time output of information - within the scope of the practicing physician - facilitate diagnosis and allow the application of sound strategies for management. The window of opportunity for aggressive control of all the traditional risk factors for cardiovascular events or sudden death with intensification of therapy is with short duration diabetes, the absence of cardiovascular disease and a history of severe hypoglycemic events. To this list we can now add autonomic dysfunction and neuropathy, which have become the most powerful predictors of risk for mortality. It seems prudent that practitioners should be encouraged to become familiar with this information and apply risk stratification in clinical practice. Several agents have become available for the correction of functional defects in the autonomic nervous system, and restoration of autonomic balance is now possible. |
| Starting Page | 4 |
| Ending Page | 18 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/46/2e/jdi0004-0004.PMC3580884.pdf |
| Alternate Webpage(s) | https://pdfs.semanticscholar.org/928b/fd745a0b7c4c274fa0dd8b7159a27f62995d.pdf |
| PubMed reference number | 23550085 |
| Volume Number | 4 |
| Journal | Journal of diabetes investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenergic Antagonists Autonomic nervous system disorders CNS disorder Cardiovascular Diseases Congenital Abnormality Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Non-Insulin-Dependent Diabetic Neuropathies Exercise Forecast of outcome Hypoglycemic Agents Myocardial Ischemia Nervous system structure Neural Tube Defects Orthostasis Oxidants Parasympathetic Nervous System Patients Prediabetes syndrome Stratification Sudden death Thioctic Acid Valsalva Maneuver nervous system disorder |
| Content Type | Text |
| Resource Type | Article |
