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The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Feinberg, Andrew P. Creese, Ian Snyder, Solomon H. |
| Copyright Year | 1976 |
| Abstract | A model of the opiate receptor is proposed which explains structure-activity relationships of opiate drugs, including (i) the unique potency of certain opiates such as etonitazene, fentanyl, phenazocine, and oripavines; (ii) the role of N-allyl substituents in conferring antagonist properties; and (iii) chemical features that afford "pure" antagonists. The model indicates mlecular mechanisms for interconversion of the opiate receptor between respective states that bind agonists or antagonists with high affinity. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.73.11.4215 |
| PubMed reference number | 186791 |
| Journal | Medline |
| Volume Number | 73 |
| Issue Number | 11 |
| Alternate Webpage(s) | http://www.pnas.org/content/73/11/4215.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.73.11.4215 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
