Nonpeptide Urotensin-II receptor agonists and antagonists: Review and structure–activity relationships

Content Provider	Semantic Scholar
Author	Lescot, Elodie Rault, Sylvain
Copyright Year	2008
Abstract	Human Urotensin-II (hU-II) is a cyclic 11-amino acid peptide that plays a role in cardiovascular homeostasis. Its receptor is a member of the class A of G-protein-coupled receptors, called GPR14. In recent years, several nonpeptide ligands have been reported in the literature. Most were identified by high-throughput screening and optimized by medicinal chemistry methods. Other nonpeptide ligands were discovered starting from the 3D structure of hU-II or other ligands. They were identified by a virtual screening approach based on a 3D pharmacophore or by structural similarity with others cyclic peptides. In this review, nonpeptide agonists and antagonists are presented in relation to structure-activity relationships.
Starting Page	680
Ending Page	690
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1016/j.peptides.2007.09.019
PubMed reference number	18022732
Journal	Medline
Volume Number	29
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0196978107003968
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0196978107003968?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.peptides.2007.09.019
Journal	Peptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article