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Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Chunquan Deng, Yiwen Liu, Yanna Xu, Yan Liu, Yanling Zhang, Li Chen, Xiongwen Xie, Mingxing Ge, Shuping |
| Copyright Year | 2018 |
| Abstract | The aims of this study were (1) to quantify changes in 3-dimensional (3D) strain in obese children using real-time 3D echocardiography (RT3DE) and 3D speckle tracking echocardiography (3DSTE), and (2) to investigate the utility of left ventricular (LV) strain variables in measuring early cardiovascular changes in children with obesity. A total of 181 obese children (study group) aged 4-18 years old were prospectively enrolled and compared with 229 healthy subjects (control group). We acquired demographic, clinical, biochemical, and 2D echocardiography/Doppler data. Also, RT3DE and 3DSTE were performed to measure LV volume, left ventricular ejection fraction (LVEF), LV mass (LVM), LV peak systolic global longitudinal strain (GLS), radial strain (GRS), circumferential strain (GCS), and global strain (GS). There were significant differences in anthropometric measurements, blood pressures, Cholesterol, C-reactive protein (CRP), Intima-media thickness (IMT), left atrium end-systolic dimension (LASD), interventricular septal end-diastolic dimension (IVSD), LV posterior wall end-diastolic dimension (LVPWD), LV end-diastolic dimension (LVEDD), LV end-systolic dimension (LVESD), LV end-diastolic volumes (LVEDV), and LV end-systolic volumes (LVESV), E and A velocities, E/A,e', e'/a', E/e', LVM, LV mass index (LVMI), GLS, GRS, GCS, and GS between the study and control groups. The receiver operating characteristic curves (ROC) for the statistically significant echocardiographic variables showed that the range of areas of ROC curves varied from 0.76 (GLS), 0.74 (GRS), 0.72 (LASD), to 0.58 (LVESD), respectively. In conclusion, LV 3D strain variables by RT3DE and 3DSTE decrease in obese children. LV 3D strain is more sensitive than other echocardiographic and vascular ultrasound variables in detecting cardiovascular changes in children with obesity. |
| Starting Page | 376 |
| Ending Page | 379 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30308043v1 |
| Alternate Webpage(s) | https://doi.org/10.1371/journal.pone.0205177 |
| DOI | 10.1371/journal.pone.0205177 |
| Journal | PloS one |
| Volume Number | 13 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 2D Doppler Echocardiography Anser rossii BCL2A1 gene Cardiovascular Abnormalities Cholesterol Circumference Coefficient Congenital Abnormality Curation Diastole Doctor of Engineering Echocardiography, Doppler, Color Ejection fraction (procedure) Heart Atrium Heart Septal Defects Indian childhood cirrhosis International Medical Terminology Kidney Failure, Chronic Left atrial structure Left ventricular ejection fraction Lithium Mass Vaccination Obesity Otitis Media ROC Curve Receiver Operator Characteristics Sclerotinia sclerotiorum hypovirus 1 Ventricular Dysfunction, Left |
| Content Type | Text |
| Resource Type | Article |
