NDLI: miR-1290 promotes lung adenocarcinoma cell proliferation and invasion by targeting SOCS4

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miR-1290 promotes lung adenocarcinoma cell proliferation and invasion by targeting SOCS4

Content Provider	Semantic Scholar
Author	Xiao, Xuelian Yang, Daheng Gong, Xue Mo, Dongping Pan, Shiyang Xu, Jian
Copyright Year	2018
Abstract	miRNAs play important roles in lung adenocarcioma (LADC) progression. We previously found that miR-1290 expression was upregulated in LADC tissue and serum samples from patients with LADC, and correlated with prognosis. However, the biological role of miR-1290 in LADC and mechanism of such role are poorly understood. Here, we found that miR-1290 overexpression promoted LADC cell proliferation, cell cycle progression and invasion, while suppressing cell apoptosis in vitro. Furthermore, miR-1290 promoted tumor growth, invasion and metastasis in vivo. miR-1290 downregulated suppressor of cytokine signaling 4 (SOCS4) at both the mRNA and protein levels by targeting SOCS4. Reduced SOCS4 level reversed the inhibitory effect of miR-1290 downregulation on cell proliferation and invasion. miR-1290 activated the JAK/STAT3 and PI3K/AKT signaling pathways by targeting SOCS4. An inverse correlation was observed between miR-1290 and SOCS4 expression in LADC tissues. Clinicopathological characteristics analysis showed that SOCS4 expression was negatively associated with higher clinical stage and lymph node metastasis. These observations suggest that miR-1290 promotes LADC cell proliferation and invasion by targeting SOCS4.
Starting Page	11977
Ending Page	11988
Page Count	12
File Format	PDF HTM / HTML
DOI	10.18632/oncotarget.24046
PubMed reference number	29552286
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=24046&path%5B%5D=75603
Journal	Oncotarget
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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