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The relationship between development of ultraviolet erythema and release of prostaglandins in guinea pig skin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adams, Stewart S. Humphries, Robert Gordon Mason, C. G. |
| Copyright Year | 2005 |
| Abstract | Ultraviolet erythema in the guinea pig has been in use for many years as a model for assessing the anti-inflammatory potency of non-steroidal anti-inflammatory agents, the degree of erythema usually being estimated about 2 h after u.v. exposure. Using a suction blister technique for obtaining tissue fluid from erythemic and normal skin of the guinea pig we have shown that prostaglandin output in ultraviolet-irradiated skin increases rapidly during the first 2 h after irradiation, at which time the erythema reaches near-maximal development. Flurbiprofen, a potent non-steroidal anti-inflammatory agent, almost totally prevents the appearance of prostaglandins in the blister fluid and significantly reduces the degree of erythema in the skin during this early period.However, in flurbiprofen-treated animals, although prostaglandin synthesis is also suppressed at 4 to 5 h after exposure and is still partially suppressed at 17 h, a well-developed erythema nevertheless appears by 4 h. This indicates the appearance of one or more non-prostaglandin mediators in the later stages of the reaction. |
| Starting Page | 473 |
| Ending Page | 476 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/BF02004708 |
| PubMed reference number | 7337071 |
| Journal | Medline |
| Volume Number | 11 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/BF02004708 |
| Alternate Webpage(s) | https://doi.org/10.1007/BF02004708 |
| Journal | Agents and Actions |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
