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Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yee, Leland Jonathan Perez, Kevin A. Tang, Jianming Leeuwen, Dirk Harmen J. Van Kaslow, Richard A. |
| Copyright Year | 2003 |
| Abstract | Cytotoxic T lymphocyte antigen-4 (CTLA4) suppresses cytotoxic T lymphocyte activity. We examined the associations of CTLA4 single-nucleotide polymorphisms (SNPs) at promoter site -318 and exon-1 site 49 with clearance of hepatitis C virus (HCV) after treatment with combination interferon-alpha plus ribavirin (IFN-alpha+R) therapy in 79 white sustained responders (SRs) and 79 nonresponders (NRs). SRs had higher frequencies of 49G, alone (odds ratio [OR], 2.3; P=.042) and tightly linked with -318C in a haplotype (OR, 2.4; P=.030). Homozygosity for the -318C-49G haplotype was even more frequent among SRs (OR, 5.2; P=.049). Comparably strong associations persisted after multivariable analysis. Relationships were not seen with non-1 genotype viruses (OR, 0.93-1.25; P>.25). Virus load also declined more rapidly in carriers of both 49G (P=.0095) and the -318C-49G haplotype. CTLA4 49G in exon 1 alone and in a haplotype with -318C promoter is associated with sustained IFNalpha+R response in white patients with HCV genotype 1 infection. |
| Starting Page | 1586 |
| Ending Page | 1595 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/187/8/10.1086/374561/2/187-8-1264.pdf?Expires=1492538757&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=IrpU1K9larbgx2UqG5OceEdNOF1y2Gdp83tEBa8DKn90uDVKiIDCxlvnaOoiVLlfro5swa~CSq6KLzYFxEy-XpuHBwu7RjwYB6SkAz~sMB7TaBdWoLbPw49dO9yG0oH76Y~NxgH4HprXVHr6E8Ni3twj7q782oHQBKlgXEAnrKXlSizqo1mjwuURSyn8XvHcWjoMC2R9kAu3TOFTCf~jy3kGAMUom66iFFfRRb54lad0cvdLcw6VDWSxTlV35b0aC2aFat6u2yBiNoxUVYUFt1DanfdljQMFnq2hN2EMFzRBP8JxH6i0d1~o7xVimGIukLtDZUyMrswcZslb6~42ag__ |
| PubMed reference number | 12696006v1 |
| Volume Number | 187 |
| Issue Number | 8 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Chemical and Drug Induced Liver Injury Cytotoxic T-Lymphocytes Forty Nine Genetic Polymorphism Haplotypes Hepatitis B Hepatitis C Virus Infection Hepatitis C, Chronic Hepatitis, Chronic Homozygote Interferon-alpha Mental association Nucleotides Patients Ribavirin Seventy Nine Single Nucleotide Polymorphism T-Lymphocyte Virus Diseases peginterferon alfa-2b |
| Content Type | Text |
| Resource Type | Article |
