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Association of CTLA4 Polymorphisms with Sustained Response to Interferon and Ribavirin Therapy for Chronic Hepatitis C Virus Infection
| Content Provider | Paperity |
|---|---|
| Author | Leland, J. Yee Tang, Jianming Richard, A. Kaslow Kevin, A. Perez Dirk, J. Van Leeuwen |
| Abstract | Cytotoxic T lymphocyte antigen-4 (CTLA4) suppresses cytotoxic T lymphocyte activity. We examined the associations of CTLA4 single-nucleotide polymorphisms (SNPs) at promoter site −318 and exon-1 site 49 with clearance of hepatitis C virus (HCV) after treatment with combination interferon-α plus ribavirin (IFN-α+R) therapy in 79 white sustained responders (SRs) and 79 nonresponders (NRs). SRs had higher frequencies of 49G, alone (odds ratio [OR], 2.3; P=.042) and tightly linked with −318C in a haplotype (OR, 2.4; P=.030). Homozygosity for the −318C-49G haplotype was even more frequent among SRs (OR, 5.2; P=.049). Comparably strong associations persisted after multivariable analysis. Relationships were not seen with non-1 genotype viruses (OR, 0.93–1.25; P>.25). Virus load also declined more rapidly in carriers of both 49G (P=.0095) and the −318C-49G haplotype. CTLA4 49G in exon 1 alone and in a haplotype with −318C promoter is associated with sustained IFNα+R response in white patients with HCV genotype 1 infection |
| Starting Page | 1264 |
| Ending Page | 1271 |
| File Format | HTM / HTML |
| ISSN | 00221899 |
| DOI | 10.1086/374561 |
| Issue Number | 8 |
| Journal | Journal of Infectious Diseases |
| Volume Number | 187 |
| e-ISSN | 15376613 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2003-04-15 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy |
