Loading...
Please wait, while we are loading the content...
Similar Documents
Use of clomiphene and luteinizing hormone/follicle stimulating hormone-releasing hormone in investigation of ovulatory failure.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ginsburg, Jean Isaacs, Abby J. Gore, M. B. Havard, C. W. H. |
| Copyright Year | 1975 |
| Abstract | A luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) test was performed in 70 women with amenorrhoea or anovulatory infertility, or both, and a clomiphene stimulation test was also performed in 24 of these patients. Most patients responded to LH/FSH-RH with significant increases in LH and FSH. In women with gonadal dysgenesis or premature ovarian failure exaggerated responses were observed after LH/FSH-RH and there was no change in high basal LH levels after clomiphene. Patients with absent or impaired responses to LH/FSH-RH failed to respond to clomiphene. All patients with anovulatory menstrual cycles responded to both LH/FSH-RH and clomiphene, while seven out of 13 amenorrhoeic patients with a normal LH/FSH-RH response showed an early LH rise during clomiphene treatment and six were unresponsive. These results suggest a difference between the two groups at hypothalamic level with consequent therapeutic implications. |
| Starting Page | 1 |
| Ending Page | 3 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bmj.com/content/bmj/3/5976/130.full.pdf |
| PubMed reference number | 1095137v1 |
| Volume Number | 3 |
| Issue Number | 5976 |
| Journal | British medical journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amenorrhea Clomiphene Congenital Abnormality Female infertility Follicle Stimulating Hormone Gonadal Dysgenesis Gonadal structure Gonadorelin Heart failure Menstrual cycle Menstruation Ovarian Failure, Premature Ovarian Follicle Patients Premature Menopause Stimulation (motivation) |
| Content Type | Text |
| Resource Type | Article |
