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Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles† †Electronic supplementary information (ESI) available: Synthetic and analytical details. See DOI: 10.1039/c8py01719k
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wilkins, Laura E. Hasan, Muhammad Fayter, Alice E. R. Biggs, Caroline I. Walker, Marc Gibson, Matthew I. |
| Copyright Year | 2019 |
| Abstract | Antifreeze proteins (AFPs) have many potential applications, ranging from cryobiology to aerospace, if they can be incorporated into materials. Here, a range of engineered AFP mutants were prepared and site-specifically conjugated onto RAFT polymer-stabilized gold nanoparticles to generate new hybrid multivalent ice growth inhibitors. Only the SNAP-tagged AFPs lead to potent 'antifreeze' active nanomaterials with His-Tag capture resulting in no activity, showing the mode of conjugation is essential. This versatile strategy will enable the development of multivalent AFPs for translational and fundamental studies. |
| Starting Page | 2986 |
| Ending Page | 2990 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C8PY01719K |
| PubMed reference number | 31303900 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/py/c8py01719k/c8py01719k1.pdf |
| Journal | Polymer chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
