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H2S gasotransmitter-responsive polymer vesicles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03576g
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yan, Qiang Sang, Wei |
| Copyright Year | 2015 |
| Abstract | Building biomimetic polymer vesicles that can sense a biological signaling molecule is a tremendous challenge at the cross-frontier of chemistry and biology. We develop a new class of oazidomethylbenzoate (AzMB)-containing block copolymer that can respond to an endogenous signaling molecule, hydrogen sulfide (H2S). Such a gasotransmitter can trigger cascade chemical reactions to sever the AzMB side functionalities, which alters the polymer amphiphilicity and further leads to a controllable disassembly of their self-assembly vesicular nanostructure. Moreover, if we introduce cystathionine g-lyase (CSE), a specific enzyme converting cysteine into H2S, onto the vesicle membrane, the polymersomes can extend their responsive scope from H2S to a specific amino acid bioactivator. We anticipate that this polymer model could open up a new avenue for constructing biosignal-triggered nanocapsules for intracellular applications. |
| Starting Page | 2100 |
| Ending Page | 2105 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29899936 |
| Volume Number | 7 |
| Alternate Webpage(s) | http://www.meplab.fudan.edu.cn/d/file/infonet/assays/2017-06-30/b6ea2af269d14753daeb4e2b9f2b2698.pdf |
| Journal | Chemical Science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
