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Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yamano, Yoshihisa Takenouchi, Norihiro Tomaru, Utano Yao, Karen Grant, Christian W. Maric, Dragan Jacobson, Steven |
| Copyright Year | 2005 |
| Abstract | CD4(+)CD25(+) Tregs are important in the maintenance of immunological self tolerance and in the prevention of autoimmune diseases. As the CD4(+)CD25(+) T cell population in patients with human T cell lymphotropic virus type I-associated (HTLV-I-associated) myelopathy/tropical spastic paraparesis (HAM/TSP) has been shown to be a major reservoir for this virus, it was of interest to determine whether the frequency and function of CD4(+)CD25(+) Tregs in HAM/TSP patients might be affected. In these cells, both mRNA and protein expression of the forkhead transcription factor Foxp3, a specific marker of Tregs, were lower than those in CD4(+)CD25(+) T cells from healthy individuals. The virus-encoded transactivating HTLV-I tax gene was demonstrated to have a direct inhibitory effect on Foxp3 expression and function of CD4(+)CD25(+) T cells. This is the first report to our knowledge demonstrating the role of a specific viral gene product (HTLV-I Tax) on the expression of genes associated with Tregs (in particular, foxp3) resulting in inhibition of Treg function. These results suggest that direct human retroviral infection of CD4(+)CD25(+) T cells may be associated with the pathogenesis of HTLV-I-associated neurologic disease. |
| Starting Page | 7635 |
| Ending Page | 7659 |
| Page Count | 25 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jci.org/articles/view/23913/version/1/pdf/render |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/23000/23913/JCI0523913.pdf |
| PubMed reference number | 15864353v1 |
| Volume Number | 115 |
| Issue Number | 5 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Autoimmune Diseases Genome Encoded Entity Human T-lymphotropic virus 1 Immune Tolerance Paraparesis, Spastic Patients Reservoir Device Component Retroviridae Infections Spinal Cord Diseases T-Cell Leukemia Viruses, Human T-Lymphocyte TRANSCRIPTION FACTOR Thrombospondins Tropical Spastic Paraparesis protein expression |
| Content Type | Text |
| Resource Type | Article |
