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Effectiveness and safety of sirolimus stent implantation for coronary in-stent restenosis: the TRUE (Tuscany Registry of Sirolimus for Unselected In-Stent Restenosis) Registry.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liistro, Francesco Fineschi, Massimo Angioli, Paolo Sinicròpi, Giuseppe Falsini, Giovanni Gori, Tommaso Ducci, Kenneth Bravi, Achille Bolognese, Leonardo |
| Copyright Year | 2006 |
| Abstract | OBJECTIVES This study sought to evaluate the effectiveness and safety of the sirolimus-eluting stent in the treatment of in-stent restenosis (ISR) in consecutive unselected patients undergoing coronary intervention in a real-world scenario. BACKGROUND Restenosis after bare metal stenting is characterized by a high rate of re-restenosis once treated with repeated percutaneous coronary intervention. METHODS The study was designed as a prospective two-center registry. We enrolled 244 patients with ISR in a native coronary artery or saphenous vein graft who had clinical indication for repeat intervention. RESULTS Sirolimus stent implantation was successful in all lesions. At 9-month follow-up, death occurred in 4 (1.6%) patients, myocardial infarction in 4 (1.6%), and ischemia-driven target lesion revascularization (TLR) in 12 (4.9%), for a cumulative event-free survival of 227 (93%). Although 9-month follow-up angiography was planned in all patients, only 150 (62%) patients completed it, and restenosis was present in 13 (8.7%) patients. Diabetes and non-ST-segment elevation acute coronary syndrome at presentation were the only independent predictors of freedom from ischemia-driven TLR and major adverse cardiac events. CONCLUSIONS Sirolimus stent implantation for the treatment of ISR is effective and safe. In diabetic patients and in those with acute coronary syndrome, the higher rate of recurrence requires further evaluation. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jacc.2006.03.039 |
| PubMed reference number | 16843174 |
| Journal | Medline |
| Volume Number | 48 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://www.onlinejacc.org/content/accj/48/2/270.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jacc.2006.03.039 |
| Journal | Journal of the American College of Cardiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
