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Long-Term Clinical Outcome after Sirolimus-Stent Implantation for in Sirolimus-Eluting Stent Restenosis
| Content Provider | SAGE Publishing |
|---|---|
| Author | Guidon, Alain Cook, Stéphane Berger, Alexandre Goy, Jean-Jacques |
| Copyright Year | 2008 |
| Abstract | Restenosis after sirolimus-eluting stents (SES) remains a clinical problem. We report our experience with the use a second SES in the first SES to treat in-SES restenosis. Twenty-seven patients with in-SES restenosis were included in the registry. In-SES restenosis was focal in 34%, diffuse in 59% and proliferative in 7%. The procedure was successful in all patients without any acute in-hospital complications. During a mean follow-up of 14 ± 7 months MACE occurred in 8 patients (30%), (1 death, 1 myocardial infarction, 4 target lesion revascularisation, 1 target vessel revascularisation and 1 patient underwent CABG). Nineteen patients (70%) had an event-free outcome. In conclusion SES placement to treat in-SES is safe and feasible and could be considered as a therapeutic option. However the incidence of MACE remains high on a long-term period.The use of stents has significantly improved the outcome of percutaneous coronary interventions (PCI) (1,2). However, despite major advances in angioplasty and stenting, in-stent restenosis remains a major limitation. Recently, drug-eluting stents and especially sirolimus-eluting stents (SES) have emerged as a very promising approach in preventing restenosis, and several different compounds have been shown to have a major impact on both the angiographic and the clinical outcome (6-9). However, even after drug eluting stents implantation in-stent restenosis (ISR) remains and represents a clinical challenge. Several approaches have been proposed to deal with ISR like plain old balloon angioplasty (POBA), rotational atherectomy, brachytherapy (1-3). Few reports are actually available about the use of SES in SES for ISR treatment. We report our experience about the use SES for treating an ISR after SES implantation. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.4137/CMC.S707?download=true |
| ISSN | 11795468 |
| Volume Number | 2 |
| Journal | Clinical medicine. Cardiology (CIC) |
| e-ISSN | 11795468 |
| DOI | 10.4137/CMC.S707 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2008-04-16 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © 2008 SAGE Publications. |
| Content Type | Text |
| Subject | Cardiology and Cardiovascular Medicine |
