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Effects of repeated immobilization stress on glutamate decar☐ylase and choline acetyltransferase in discrete brain regions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gottesfeld, Zehava Kvetnˇansky´, Richard Kopin, Irwin J. Jacobowitz, David M. |
| Copyright Year | 1978 |
| Abstract | A variety of stressors trigger the release of hypothalamic corticotropin releasing factor (CRF) which activates the pituitary-adrenal axis. This action is manifested by the release of adrenocorticotrophic hormone (ACTH) and subsequently of adrenal corticoids. The secretion of CRF is thought to be regulated, at least in part, by a combined facilitatory and inhibitory action, possibly mediated by the amines, acetylcholine and gamma-aminobutyric acid (GABA) (for review see refs. 7 and 21). This stress is also attended by striking CNS-mediated increases in sympathetic-adrenal medullary discharge. The initiation of adrenergic activation by stress involves pathways similar to those controlling hypothalamic releasing factors which control pituitary hormones, and it is likely that similar neurotransmitters are involved. A large number of studies have focused attention on the role of neurotransmitters in mediating the response to stress, but only recently has information been obtained from studies which combine microdissection of discrete brain regions with sensitive microassay techniques. These studies have shown that differential changes of catecholamines and serotonin occur in discrete brain regions in response to various stressors 12, 15,17,1s. Comparable knowledge of the behavior of cholinergic and GABAergic neurons in individual nuclei is not available. Such information is of significance, since it could reveal a functional role of certain discrete brain areas. The purpose of this work was to compare the effect of immobilization stress on glutamate decarboxylase (GAD) and choline acetyltransferase (CHAT), marker enzymes of GABAergic and cholinergic neurons, respectively, in discrete brain regions, and to study the sequence of changes that occur after short-term as well as prolonged stress when adaptation is likely to occur. The results demonstrate differential changes in GAD and ChAT activity in specific nuclei. Male Sprague-Dawley rats (300-350 g, specific pathogen-free) purchased from Taconic Farms were used. Food and water was provided ad libitum. The animals were |
| Starting Page | 374 |
| Ending Page | 378 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(78)90267-6 |
| PubMed reference number | 567089 |
| Journal | Medline |
| Volume Number | 152 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0006899378902676 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0006899378902676?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2878%2990267-6 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
