NDLI: Heterologous expression of porcine reproductive and respiratory syndrome virus glycoprotein 5 in Bordetella bronchisepticaaroA mutant

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Heterologous expression of porcine reproductive and respiratory syndrome virus glycoprotein 5 in Bordetella bronchisepticaaroA mutant

Content Provider	Semantic Scholar
Author	Seo, Ja Young Kim, Tae Jung
Copyright Year	2016
Abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important disease around the globe. Protection against this virus remains problematic. Here, we evaluated antibody (IgG & IgA) inducibility of a heterologous PRRSV glycoprotein 5 (GP5) expressed in a live attenuated Bordetella bronchisepticaaroA mutant strain (BBS-GP5). Mice and pigs were primed with recombinant GP5 (rGP5) subcutaneously followed by boosting with live BBS-GP5. As a result, anti-GP5 IgG was induced in both mice (P<0.001) and pigs (P<0.1). Pigs were challenged with live PRRSV (VR2332). Viral RNA was found to be significantly (P<0.01) removed in the vaccinated pig group. Overall, BBS-GP5 is a good candidate as a live attenuated vaccine against PRRSV infection.
Starting Page	1625
Ending Page	1629
Page Count	5
File Format	PDF HTM / HTML
PubMed reference number	27349762
Volume Number	78
Journal	The Journal of veterinary medical science
Language	English
Access Restriction	Open
Subject Keyword	BBIP1 gene GP5 gene Immunoglobulin A Murine sarcoma viruses Platelet Glycoprotein V, human Porcine Reproductive and Respiratory Syndrome Porcine respiratory and reproductive syndrome virus Porcine species Recombinant Growth Hormone Recombinants Reproduction Vaccines, Attenuated genus Bordetella
Content Type	Text
Resource Type	Article

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