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An ultrasensitive and selective electrochemical sensor for determination of estrone 3-sulfate sodium salt based on molecularly imprinted polymer modified carbon paste electrode
| Content Provider | Semantic Scholar |
|---|---|
| Author | Song, Han Ho Wang, Yuli Zhang, Lu Tian, Liping Zhao, Na Han, Yajie Zhao, Feilang Ying, Xue Li, Yingchun |
| Copyright Year | 2017 |
| Abstract | AbstractA highly sensitive and selective electrochemical sensor based on carbon paste electrode (CPE) modified with molecularly imprinted polymers (MIPs) has been developed for the determination of estrone 3-sulfate sodium salt (ESS). MIPs were prepared in polar medium via bulk polymerization and characterized by scanning electron microscopy and infrared spectroscopy. Cyclic voltammetry was performed to the study preparation process and binding behavior of the MIP-modified CPE (MIP/CPE) toward ESS. The conditions for preparing MIPs and MIP/CPE as well as ESS detection were optimized. Under the optimal experimental conditions, the detection linear range for ESS is 4 × 10−12 to 6 × 10−9 M with a limit of detection of 1.18 × 10−12 M (S/N = 3). In addition, the sensor exhibits high binding affinity toward ESS over its structural analogues with excellent repeatability and stability. The fabricated MIP/CPE was then successfully employed to detect ESS in pregnant mare urine (PMU) without any pretreatment, and the average recoveries were from 99.6 to 104.9% with relative standard deviation less than 3.0%. High-performance liquid chromatography was adopted as a reference to validate the established approach in detecting ESS and their results showed good agreement. The as-prepared sensor has high potential to be a decent tool for on-site determination of ESS in PMU in a fast and convenient manner. Graphical Abstractᅟ |
| Starting Page | 6509 |
| Ending Page | 6519 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00216-017-0598-x |
| PubMed reference number | 28889259 |
| Journal | Medline |
| Volume Number | 409 |
| Alternate Webpage(s) | https://static-content.springer.com/esm/art:10.1007%2Fs00216-017-0598-x/MediaObjects/216_2017_598_MOESM1_ESM.pdf |
| Journal | Analytical and Bioanalytical Chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
