NDLI: Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy.

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Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy.

Content Provider	Semantic Scholar
Author	Esclapez, Monique Hirsch, June C. Khazipov, Roustem Ben-Ari, Yehezkiel Bernard, Christophe
Copyright Year	1997
Abstract	Patch-clamp recordings of CA1 interneurons and pyramidal cells were performed in hippocampal slices from kainate- or pilocarpine-treated rat models of temporal lobe epilepsy. We report that gamma-aminobutyric acid (GABA)ergic inhibition in pyramidal neurons is still functional in temporal lobe epilepsy because: (i) the frequency of spontaneous GABAergic currents is similar to that of control and (ii) focal electrical stimulation of interneurons evokes a hyperpolarization that prevents the generation of action potentials. In paired recordings of interneurons and pyramidal cells, synchronous interictal activities were recorded. Furthermore, large network-driven GABAergic inhibitory postsynaptic currents were present in pyramidal cells during interictal discharges. The duration of these interictal discharges was increased by the GABA type A antagonist bicuculline. We conclude that GABAergic inhibition is still present and functional in these experimental models and that the principal defect of inhibition does not lie in a complete disconnection of GABAergic interneurons from their glutamatergic inputs.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.94.22.12151
PubMed reference number	9342378
Journal	Medline
Volume Number	94
Issue Number	22
Alternate Webpage(s)	https://yehezkelbenari.files.wordpress.com/2015/07/operative-gabaergic-inhibition-in-hippocampal-ca1-pyramidal-neurons-in-experimental-epilepsy.pdf
Alternate Webpage(s)	http://www.inmed.fr/wp-content/uploads/2014/04/934378.pdf
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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