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Ethanol-induced taste aversions: lack of involvement of acetaldehyde and the area postrema.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hunt, Walter A. Rabin, Bernard M. |
| Copyright Year | 1987 |
| Abstract | Two experiments were run to evaluate the role of acetaldehyde and the area postrema in the acquisition of an ethanol-induced conditioned taste aversion. An ethanol-induced taste aversion was observed in male Sprague-Dawley rats with a dose of 4 g/kg. PO, but not after doses of 1 or 2 g/kg. Pretreatment with 4-methylpyrazole (8 mg/kg, IP), which itself did not induce an aversion as compared to pyrazole (68 mg/kg, IP) that did, and/or prior application of lesions of the area postrema had no influence on the development of an ethanol-induced taste aversion. The results indicate that ethanol-induced taste aversion learning does not result from the metabolism of ethanol to acetaldehyde and does not, like other toxins, involve the mediation of the area postrema. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0741-8329(87)90039-5 |
| Alternate Webpage(s) | http://www.dtic.mil/dtic/tr/fulltext/u2/a183501.pdf |
| PubMed reference number | 3593531 |
| Alternate Webpage(s) | https://doi.org/10.1016/0741-8329%2887%2990039-5 |
| Journal | Medline |
| Volume Number | 4 |
| Issue Number | 3 |
| Journal | Alcohol |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
