Loading...
Please wait, while we are loading the content...
Similar Documents
Deoxynivalenol (vomitoxin)-induced conditioned taste aversions in rats are mediated by the chemosensitive area postrema
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ossenkopp, Klaus-Peter Hirst, Maurice Rapley, William A. |
| Copyright Year | 1994 |
| Abstract | The present experiments used a conditioned aversion to a novel saccharin taste to assess the aversive effects of deoxynivalenol (vomitoxin) administration, and to examine the putative mediating role of the chemosensitive area postrema (AP). In experiment 1 adult male rats drank a novel 0.15% saccharin solution followed by injection of deoxynivalenol (n = 7; 0.125 mg/kg, IP) or vehicle (n = 7; propylene glycol, 0.5 ml/kg). In subsequent two-bottle preference tests the rats conditioned with deoxynivalenol displayed significantly (p < 0.01) lower absolute and relative saccharin intake levels in comparison to control rats which exhibited a strong preference for saccharin solution. In experiment 2 adult male rats received area postrema ablations (n = 6) or sham lesions (n = 6). On two conditioning days all rats drank a novel 0.15% saccharin solution followed by injections of deoxynivalenol (0.125 mg/kg, IP). In subsequent two-bottle preference tests the sham-lesioned rats displayed a significant (p < 0.01) aversion to the saccharin stimulus, relative to the area postrema-ablated rats which exhibited a preference for the saccharin solution. Thus, systemic administration of deoxynivalenol, following a novel taste, induced conditioned taste aversions which were mediated by the area postrema. |
| Starting Page | 363 |
| Ending Page | 367 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(94)90024-8 |
| PubMed reference number | 8146230 |
| Journal | Medline |
| Volume Number | 47 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0091305794900248 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0091305794900248?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2894%2990024-8 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
