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A human protein related to yeast Cdc6p.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Williams, R. Steve |
| Copyright Year | 1997 |
| Abstract | The unstable proteins Cdc6p and cdc18+ are essential and rate limiting for the initiation of DNA replication in Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively, and also participate in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. We have identified Xenopus and human proteins closely related to Cdc6p/cdc18. The human protein, p62(cdc6), is encoded on chromosome 17q21.3 and includes putative cyclin-dependent kinase phosphorylation sites, destruction boxes, a nucleotide binding/ATPase domain, and a potential leucine zipper. Expression of p62(cdc6) mRNA and protein is suppressed in human diploid fibroblasts made quiescent by serum starvation, and peaks as cells reenter the cell cycle and replicate DNA following serum stimulation. Conservation of structure among proteins involved in initiation suggests that fundamental features of replication complexes are maintained in all eukaryotes. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/94/1/142.full.pdf |
| PubMed reference number | 8990175v1 |
| Volume Number | 94 |
| Issue Number | 1 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 17q21.3 CDC6 protein, human Cell Cycle Checkpoints Cyclin-Dependent Kinases Cyclins DNA Replication Killer Factors, Yeast Leucine Zippers Mitosis Nucleotides Transcription Initiation Unstable Medical Device Problem |
| Content Type | Text |
| Resource Type | Article |
