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1-Tetralinyl as carboxamide - protecting group for Asparagine and Application to Na-t-Butyloxycarbonyl (Boc) solid - phase peptide synthesis of Oxytocin,
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bhalendu, Bhatt |
| Copyright Year | 2001 |
| Abstract | Oxytocin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc strategy. Benzyl group was used in the protection of sulfhydryl group of cysteine and tyrosine side-chain. Benzhydryl and tetralinyl groups were used in the protection of glutamine and asparagine side-chains respectively. TFMSA-TFA-thioanisole-1,2ethanedithiol (2:20:2:1 v/v) was used on the peptide-resin under different cleavage conditions to obtain oxytocin in a one-pot reaction. The cleavage at 40°C for two hours gave oxytocin quantitatively. Oxytocin could be isolated in 56% yield. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://profiles.uonbi.ac.ke/dorata/files/scan0013.pdf |
| Alternate Webpage(s) | https://profiles.uonbi.ac.ke/ayusuf/files/cmr_6_2_tetralinyl_oxytocin_2014_.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |