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Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms
| Content Provider | Semantic Scholar |
|---|---|
| Author | Diederich, Christine |
| Copyright Year | 2015 |
| Abstract | The aim of this doctoral thesis was to investigate (micro-) structural alterations of the brain in patients with idiopathic-generalized epilepsy. 25 patients, subdivided in IGE (13) and in the subclass juvenile myoclonic epilepsy (JME, 12), as well as 44 healthy controls were scanned at a 3T MRI-Scanner at the MR Research Group Gottingen with conventional and new MRI-protocols (T1-weighted images, DTI, T1 Relaxometry and semi-quantitative magnetization transfer mapping). Using TBSS for the DTI data, a comparison between patients and healthy controls shows large changes in white matter tracts (FA reductions and MD increases). Voxel-based morphometry of the T1-weighted images, T1 Relaxometry and MT-mapping from 13 patients with IGE and 11 patients with JME compared to 38 controls does not detect significant alterations. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ediss.uni-goettingen.de/bitstream/handle/11858/00-1735-0000-0023-9633-F/CD%20-Online%20Version.pdf?sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
