NDLI: The molecular pharmacology of organic anion transporters: from DNA to FDA?

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The molecular pharmacology of organic anion transporters: from DNA to FDA?

Content Provider	Semantic Scholar
Author	Eraly, Satish A. Bush, Kevin T. Sampogna, Rosemary V. Bhatnagar, Vibha Nigam, Sanjay K.
Copyright Year	2004
Abstract	Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.
Starting Page	292
Ending Page	295
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://molpharm.aspetjournals.org/content/molpharm/65/3/479.full.pdf
PubMed reference number	14978224v1
Volume Number	65
Issue Number	3
Journal	Molecular pharmacology
Language	English
Access Restriction	Open
Subject Keyword	Adverse reaction to drug Anion Exchange Protein 1, Erythrocyte Anions Membrane Transport Proteins Organic Anion Transporters Pharmacogenetics Pharmacology Solute Carrier Organic Anion Transporter Family Member 1b1
Content Type	Text
Resource Type	Article

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