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Cisplatin ototoxicity and the possibly protective effect of α-melanocyte stimulating hormone
| Content Provider | Semantic Scholar |
|---|---|
| Author | Heijmen, P. S. Klis, Sjaak F. L. Groot, John C. M. J. De Smoorenburg, Guido F. |
| Copyright Year | 1999 |
| Abstract | It is known that adrenocorticotrophic hormone (ACTH)-derived peptides, the so-called melanocortins, can reduce cisplatin-induced neurotoxicity. Recently, our group has found that cisplatin-induced ototoxicity can also be reduced or prevented by treatment with the synthetic melanocortin-like peptide, ORG 2766 (Hamers et al., 1994; De Groot et al., 1997). The present study was designed to investigate the possibly ameliorating effects of the physiologically more relevant naturally occurring neuropeptide α-melanocyte stimulating hormone (α-MSH) upon cisplatin ototoxicity and to compare its protective effects to those of ORG 2766. For eight consecutive days guinea pigs were treated with cisplatin at a concentration of either 1.5 mg/kg/day or 2 mg/kg/day. Animals were co-treated with either α-MSH (75 μg/kg/day), ORG 2766 (75 μg/kg/day), or a sham injection containing physiological saline. Electrocochleography and hair cell counts were performed. Treatment with 1.5 mg/kg/day cisplatin resulted in a large variability of the morphological and electrophysiological data, a variability that might have masked possible effects of ORG 2766 and α-MSH. Treatment with 2 mg/kg/day cisplatin caused less variable, severe reductions in the compound action potentials and cochlear microphonics combined with basal and middle-turn outer hair cell loss in five out of six animals. However, in the α-MSH co-treated groups, two out of six animals could be classified as normal, two animals as moderately affected and two animals as severely affected. In the ORG 2766 co-treated group we found three animals that were not affected and three animals that were severely affected. We conclude that the protective effects of α-MSH and ORG 2766 co-treatment are comparable and that α-MSH might be clinically useful in protecting against cisplatin-induced ototoxicity. |
| Starting Page | 27 |
| Ending Page | 39 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0378-5955(98)00194-4 |
| Volume Number | 128 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0378595598001944 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0378595598001944?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0378-5955%2898%2900194-4 |
| Journal | Hearing Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
