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Systemic co-treatment with α-melanocyte stimulating hormone delays hearing loss caused by local cisplatin administration in guinea pigs
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wolters, Francisca L. C. Klis, Sjaak F. L. Groot, John C. M. J. De Hamers, Frank P. T. Smoorenburg, Guido F. |
| Copyright Year | 2003 |
| Abstract | It has previously been demonstrated that ototoxicity induced by systemic administration of cisplatin is reduced by concomitant administration of melanocortins, like alpha-melanocyte stimulating hormone (alpha-MSH). However, these experiments were hampered by large interanimal variability. Therefore, we re-investigated the effects of systemically administered alpha-MSH during local (intracochlear) administration of cisplatin. Guinea pigs, implanted with a round-window electrode, allowing daily monitoring of the compound action potentials (CAPs), and a mini-osmotic pump, pumping either 0.5 microl/h physiological saline or cisplatin solution (15 microg/ml), were co-treated daily with a subcutaneous bolus injection of either alpha-MSH (75 microg/kg) or physiological saline for 1 week or until the electrocochleogram showed a persistent decrease in CAP amplitude (40 dB threshold shift at 8 kHz). Next, the animals were sacrificed and the cochleas were processed for histology. After 2-3 days, cisplatin alone caused a threshold shift at all frequencies (2-16 kHz). Co-administration with alpha-MSH consistently delayed the criterion threshold shift by 1 day. When the 40 dB criterion had been reached, similar outer hair cell losses in both the cisplatin/alpha-MSH- and cisplatin/saline-treated groups were observed. This experiment confirms that direct administration of cisplatin into the cochlea results in considerably less interanimal variability than systemic administration and that co-treatment with alpha-MSH delays cisplatin ototoxicity. Since cisplatin was delivered directly to the cochlea, the ameliorating effect of alpha-MSH probably involves a cochlear target. |
| Starting Page | 53 |
| Ending Page | 61 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0378-5955(03)00080-7 |
| PubMed reference number | 12742238 |
| Journal | Medline |
| Volume Number | 179 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0378595503000807 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0378595503000807?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0378-5955%2803%2900080-7 |
| Journal | Hearing Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
