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Peptide Bond Modification for Metal Coordination: 3. Metal-Binding Properties of Phosphorus-Based Pseudo-peptides
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ye, Yunpeng Marshall, Garland R. |
| Copyright Year | 2001 |
| Abstract | Phosphorus-based peptidomimetics have been attractive target compounds during research and development of metalloproteinase inhibitors [1]. Their inhibiting activities are thought to be associated with mimicry of the metal-mediated transition state or tet-rahedral-intermediate of the amide hydrolysis [2]. Because of the important roles of metal ions in the structures and functions of metalloproteinases, we envision that systematic investigation of the metal binding properties of phosphorus-based peptidomimetics should provide better understanding of their mechanism of action and assist the rational design of potent and specific inhibitors. |
| Starting Page | 595 |
| Ending Page | 596 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/978-94-010-0464-0_276 |
| Alternate Webpage(s) | http://www.cmd.wustl.edu/Publications/17APSYePeptideBond3.pdf |
| Alternate Webpage(s) | http://www.cmd.wustl.edu/Publications/ye.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
